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杨松

2023-02-24 12:35:59 来源：永利娱高ylg060net 浏览数：0

	职称：教授
	学院系所：微生物系
	学科领域：微生物代谢和合成生物工程
	联系电话：18630992206
	电子邮件：yangsong1209@163.com
	通讯地址：科技楼3032室
个人简介：
天津大学获本、硕、博学位（1996-2006），师承合成生物学专家、中国科学院院士元英进教授，美国华盛顿大学博士后（2007-2012），合作导师美国科学院院士Mary Lidstrom教授。目前是青岛农业大学教授、博导，永利娱高ylg060net院长，兼任山东省应用真菌重点实验室主任、首席，中国生物化工专委会常委，中国一碳生物技术专委会常委，山东省微生物学会理事，山东省科技特派员，青岛种业创新中心应用微生物与食用菌分中心主任，青岛生物沼气微生物高值化利用国际合作基地主任。一直工作在微生物代谢和合成生物工程，主要包括甲基细菌代谢调控与细胞工厂构建、农作物甲基益生菌研发及食药用菌天然药物合成。在Nature Communications、 Biotechnology Advances、Metabolic Engineering、Bioresource Technology、 mBio、Journal of Agricultural and Food Chemistry、 Applied Environmental Microbiology、 Biotechnology for Biofuels、Journal of Chromatogr A、 Applied Microbiology and Biotechnology 等发表论文 60 多篇，授权发明专利 8项，学术著作4部，山东省优秀研究生指导教师。
教学情况：
本科教学：《微生物（双语）》、《生命科学前言讲座》、《生物科学专业导论》研究生教学：《微生物合成生物技术》。学术著作：《微生物学实验》，高等教育出版社，副主编；《酶工程》，科学出版社，参编。
科研方向：
甲基细菌代谢工程、农业益生菌、微生物饲料蛋白、食药用菌天然活性物质合成
科研项目：
1. 国家自然科学基金面上项目，光合驱动高代谢得率甲醇基混菌构建及发酵解耦负碳转化，2025-2028. 2.国家自然科学基金面上项目，甲基杆菌天然色素蛋白复合体的重塑及甲醇微氧发酵转化，2021-2024。 3.国家重点研发计划子课题，生物转化甲醇合成能源及精细化学品,2021-2024。 4.国家自然科学基金面上项目，甲基杆菌异源一碳协作同化通道的构建及其强化甲醇转化，2018-2021。 5.国家自然科学基石油化工联合基金项目，甲基微菌基因组定向进化与异源基因组装转化甲醇成丁二烯的研究， 2015-2017。 6.山东省重大科技创新工程项目，基于大数据的食用菌特色种质及活性成分的研发与示范项目，2022-2024。 7.山东省重点研发计划，沼气生物合成丁二烯新技术及工艺的开发，2016-2018。 8.山东省自然科学基金面上项目，乌灵参发酵提取物抗炎免疫调节机制的代谢组学研究，2013-2016。 9.青岛生物制造智库项目，强化甲基杆菌一碳同化效率与大幅提高甲醇成生物丙烯酸，2020-2021。
科研奖励：
山东省优秀研究生指导教师
发明专利：
1. 杨松、周狄霏、张聪、宋亚珍、王浩然，提高α-变形菌门甲基营养菌在植物叶际生长定殖的方法，ZL 202211171282.2 2.杨松、朱琳、马增新、张长太、宋琳、宋亚珍、孙静，一株高效利用甲酸的扭脱甲基杆菌进化菌及其应用，ZL 202111518064.7 3.杨松、杨靖、张长太、莫旭华、朱丽萍，一种丁二烯生产菌及其生产丁二烯的方法， ZL 201810542064.2 4.杨松、姚陆、朱丽萍、徐晓燕，一种糖苷化合物及其制备方法，ZL201610394615.6
代表性论文：
1.Improvement of plant growth and fruit quality by introducing a phosphoribosylpyrophosphate synthetase mutation into Methylorubrum populi.Zhang C, Yao L, Zhang MM, Tian DD, Wu J, Hu YZ, Bao K, Ma ZX, Tan LL, Yang S.J Appl Microbiol. 2025 Jan 6;136(1):lxaf013. doi: 10.1093/jambio/lxaf013. 2. Multi-target anti-diabetic styrylpyrones from Phellinus igniarius: Inhibition of α-glucosidase, protein glycation, and oxidative stress.Yu G, Fu X, Mo X, Tan L, Yang S.Int J Biol Macromol. 2024 Oct;278(Pt 2):134854. doi: 10.1016/j.ijbiomac.2024.134854. Epub 2024 Aug 19 3. Interspecific cross-talk: The catalyst driving microbial biosynthesis of secondary metabolites.Yu G, Ge X, Li W, Ji L, Yang S.Biotechnol Adv. 2024 Nov;76:108420. doi: 10.1016/j.biotechadv.2024.108420. Epub 2024 Aug 9 4. Phosphoribosylpyrophosphate synthetase as a metabolic valve advances Methylobacterium/Methylorubrum phyllosphere colonization and plant growth.Zhang C, Zhou DF, Wang MY, Song YZ, Zhang C, Zhang MM, Sun J, Yao L, Mo XH, Ma ZX, Yuan XJ, Shao Y, Wang HR, Dong SH, Bao K, Lu SH, Sadilek M, Kalyuzhnaya MG, Xing XH, Yang S.Nat Commun. 2024 Jul 16;15(1):5969. doi: 10.1038/s41467-024-50342-9. 5. Heterologous production of 3-hydroxypropionic acid in Methylorubrum extorquens by introducing the mcr gene via a multi-round chromosomal integration system based on cre-lox71/lox66 and transposon.Zhu L, Song Y, Ma S, Yang S.Microb Cell Fact. 2024 Jan 3;23(1):5. doi: 10.1186/s12934-023-02275-z. 6. Engineering photo-methylotrophic Methylobacterium for enhanced 3-hydroxypropionic acid production during non-growth stage fermentation.Ma ZX, Feng CX, Song YZ, Sun J, Shao Y, Song SZ, Wan B, Zhang C, Fan H, Bao K, Yang S.Bioresour Technol. 2024 Feb;393:130104. doi: 10.1016/j.biortech.2023.130104. 7. Characterization of C30 carotenoid and identification of its biosynthetic gene cluster in Methylobacterium extorquens AM1.Mo XH, Sun YM, Bi YX, Zhao Y, Yu GH, Tan LL, Yang S.Synth Syst Biotechnol. 2023 Aug 9;8(3):527-535. doi: 10.1016/j.synbio.2023.08.002. eCollection 2023 Sep. 8. Discovery of Novel Terpenoids from the Basidiomycete Pleurotus ostreatusthrough Genome Mining and Coculture Optimization.Yu G, Ge X, Wang Y, Mo X, Yu H, Tan L, Yang S.J Agric Food Chem. 2023 Jul 26;71(29):11110-11123. doi: 10.1021/acs.jafc.3c03276. 9.Liping Zhu, Yao Su , Zhiheng Ma, Lizhong Guo, Song Yang, Hao Yu，Comparative proteomic analysis reveals differential protein expression of Hypsizygus marmoreus in response to different light qualities，Int J Biol Macromol 2022 Dec 31;223(Pt A):1320-1334. 10.Xiao-Jie Yuan, Wen-Jing Chen, Zeng-Xin Ma, Qian-Qian Yuan, Lian He, Min Zhang, XuHua Mo, Chong Zhang, Chang-Tai Zhang, Meng-Ying Wang, Dong-Dong Li, Xin-Hui Xing, Song Yang, Rewiring the native methanol assimilation metabolism by incorporating the heterologous ribulose monophosphate cycle into Methylorubrum extorquens, Metab Eng. 2021 Jan 22;64:95-110. doi: 10.1016/j.ymben.2021.01.009. 11.Zeng-xin Ma, Min Zhang, Chang-tai Zhang, Hui Zhang, Xu-hua Mo, Xin-hui Xing, Song Yang, Metabolomic analysis for engineering bioconversion of methanol into isobutanol in Methylorubrum extorquens AM1, Biotechnology Journal, Feb 17;e2000413. doi: 10.1002/biot.202000413. 12.Liping Zhu, Song SZ, Song Yang. Gene repression using synthetic small regulatory RNA in Methylorubrumextorquens. J Appl Microbiol. 2021 Dec;131(6):2861-2875. 13.张卉，袁姚梦，张翀，杨松，邢新会，合成甲基营养细胞工厂工程化研究进展及未来展望，《合成生物学》， 2021，2（2）：222-233 . 14.Xu-Hua Mo, Hui Zhang, Tian-Min Wang, Chong Zhang, Cong Zhang, Xin-Hui Xing, Song Yang. Establishment of CRISPR interference in Methylorubrum extorquens and application of rapidly mining a new phytoene desaturase involved in carotenoid biosynthesis. Appl Microbial Biotechnol. 2020, 104(10):4515-4532. 15.Xiao-Ting Shen , Xu-Hua Mo, Li-Ping Zhu, Ling-Ling Tan, Feng-Yu Du, Qian-Wen Wang, Yuan-Ming Zhou, Xiao-Jie Yuan, Bin Qiao, Song Yang. Unusual and Highly Bioactive Sesterterpenes Synthesized by Pleurotus ostreatus during Coculture with Trametes robiniophila Murr. Appl Environ Microbiol. 2019 Jul 1;85(14) pii: e00293-19（热点文章）. 16.Jing Yang, Chang-Tai Zhang, Xiao-Jie Yuan, Min Zhang, Xu-Hua Mo, Ling-Ling Tan, LiPing Zhu, Wen-Jing Chen, Ming-Dong Yao, Bo Hu, Song Yang. Metabolic engineering of Methylobacterium extorquens AM1 for the production of butadiene precursor. Microb Cell Fact. 2018 Dec 20;17(1):194. 17.Xiao-Yan Xu, Xiao-Ting Shen, Xiao-Jie Yuan, Yuan-Ming Zhou, Huan Fan, Li-Ping Zhu, Feng-Yu Du, Martin Sadilek, Jie Yang, Bin Qiao, Song Yang. Metabolomics investigation of an association of induced features and corresponding fungus during the co-culture of Trametes versicolor and Ganoderma applanatum. Front Microbiol. 2018 Jan 9;8:2647. 18.Yi-Ming Yang, Wen-Jing Chen, Jing Yang, Yuan-Ming Zhou, Bo Hu, Min Zhang, Li-Ping Zhu, Guang-Yuan Wang, Song Yang. Production of 3-hydroxypropionic acid in engineered Methylobacterium extorquens AM1 and its reassimilation through a reductive route, Microb Cell Fact. 2017 Oct 30;16(1):179. 19.Bo Hu, Yi-Ming Yang, David A. Beck, Qian-Wen Wang, Wen-Jing Chen, Jing Yang, Mary E. Lidstrom, Song Yang. Comprehensive molecular characterization of Methylobacterium extorquens AM1 adapted for 1-butanol tolerance. Biotechnol Biofuels. 2016 Apr 11;9:84. 20.Song Yang, Jamin C. Hoggard, Mary E. Lidstrom, Robert E. Synovec. Comprehensive discovery of 13C labeled metabolites in the bacterium Methylobacterium extorquens AM1 using gas chromatography-mass spectrometry. J Chromatogr A. 2013 Nov 22;1317:175-85. 21.Song Yang, Jeremy S. Nadeau, Elizabeth M. Humston-Fulmer, Jamin C. Hoggard, Mary E. Lidstrom, Robert E. Synovec. Gas chromatography-mass spectrometry with chemometric analysis for determining ¹²C and ¹³C labeled contributions in metabolomics and ¹³C flux analysis. J Chromatogr A. 2012 Jun 1;1240:156-64. 22.Marina G Kalyuzhnaya, Song Yang, Rozova ON, et al. Highly efficient methane biocatalysis revealed in a methanotrophic bacterium. Nat Commun. 2013;4:2785. 23.E. Latypova, Song Yang, Y. Wang, T. Wang, T. A.Chavkin, M. Hackett, H. Schäfer, M. G. Kalyuzhnaya. Genetics of the glutamate-mediated methylamine utilization pathway in the facultative methylotrophic beta-proteobacterium Methyloversatilis universalis FAM5. Molecular Microbiology. 2010 75(2):426-439.